Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development
نویسندگان
چکیده
The authors present a novel ultra scale-down (USD) methodology for the characterization of flocculation processes. This USD method, consisting of a multiwell, magnetically agitated system that can be fitted on the deck of a liquid handling robot, mimicked the flocculation performance of a nongeometrically similar pilot-scale vessel representing greater than three orders of magnitude scale-up. Mixing scales (i.e. macromixing, mesomixing or micromixing) modulated the flocs' size and determined the success of some of the scale-up correlations reviewed in the literature.
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